Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
Identifieur interne : 000536 ( Main/Exploration ); précédent : 000535; suivant : 000537Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
Auteurs : S Munir Alam [États-Unis] ; Baptiste Aussedat [États-Unis] ; Yusuf Vohra [États-Unis] ; R Ryan Meyerhoff [États-Unis] ; Evan M. Cale [États-Unis] ; William E. Walkowicz [États-Unis] ; Nathan A. Radakovich [États-Unis] ; Kara Anasti [États-Unis] ; Lawrence Armand [États-Unis] ; Robert Parks [États-Unis] ; Laura Sutherland [États-Unis] ; Richard Scearce [États-Unis] ; M Gordon Joyce [États-Unis] ; Marie Pancera [États-Unis] ; Aliaksandr Druz [États-Unis] ; Ivelin S. Georgiev [États-Unis] ; Tarra Von Holle [États-Unis] ; Amanda Eaton [États-Unis] ; Christopher Fox [États-Unis] ; Steven G. Reed [États-Unis] ; Mark Louder [États-Unis] ; Robert T. Bailer [États-Unis] ; Lynn Morris [Afrique du Sud] ; Salim S. Abdool-Karim [Afrique du Sud] ; Myron Cohen [États-Unis] ; Hua-Xin Liao [États-Unis] ; David C. Montefiori [États-Unis] ; Peter K. Park [États-Unis] ; Alberto Fernández-Tejada [États-Unis] ; Kevin Wiehe [États-Unis] ; Sampa Santra [États-Unis] ; Thomas B. Kepler [États-Unis] ; Kevin O. Saunders [États-Unis] ; Joseph Sodroski [États-Unis] ; Peter D. Kwong [États-Unis] ; John R. Mascola [États-Unis] ; Mattia Bonsignori [États-Unis] ; M Anthony Moody [États-Unis] ; Samuel Danishefsky [États-Unis] ; Barton F. Haynes [États-Unis]Source :
- Science translational medicine [ 1946-6242 ] ; 2017.
Abstract
A goal for an HIV-1 vaccine is to overcome virus variability by inducing broadly neutralizing antibodies (bnAbs). One key target of bnAbs is the glycan-polypeptide at the base of the envelope (Env) third variable loop (V3). We have designed and synthesized a homogeneous minimal immunogen with high-mannose glycans reflective of a native Env V3-glycan bnAb epitope (Man9-V3). V3-glycan bnAbs bound to Man9-V3 glycopeptide and native-like gp140 trimers with similar affinities. Fluorophore-labeled Man9-V3 glycopeptides bound to bnAb memory B cells and were able to be used to isolate a V3-glycan bnAb from an HIV-1-infected individual. In rhesus macaques, immunization with Man9-V3 induced V3-glycan-targeted antibodies. Thus, the Man9-V3 glycopeptide closely mimics an HIV-1 V3-glycan bnAb epitope and can be used to isolate V3-glycan bnAbs.
DOI: 10.1126/scitranslmed.aai7521
PubMed: 28298421
Affiliations:
- Afrique du Sud, États-Unis
- Caroline du Nord, Maryland, Massachusetts, Washington (État), État de New York
- Chapel Hill (Caroline du Nord)
- Université de Caroline du Nord à Chapel Hill
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Reed</name><affiliation wicri:level="2"><nlm:affiliation>Infectious Disease Research Institute, Seattle, WA 98102, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Disease Research Institute, Seattle, WA 98102</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Louder, Mark" sort="Louder, Mark" uniqKey="Louder M" first="Mark" last="Louder">Mark Louder</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bailer, Robert T" sort="Bailer, Robert T" uniqKey="Bailer R" first="Robert T" last="Bailer">Robert T. Bailer</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Morris, Lynn" sort="Morris, Lynn" uniqKey="Morris L" first="Lynn" last="Morris">Lynn Morris</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Communicable Diseases, Johannesburg 2131, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>National Institute for Communicable Diseases, Johannesburg 2131</wicri:regionArea><wicri:noRegion>Johannesburg 2131</wicri:noRegion></affiliation></author><author><name sortKey="Abdool Karim, Salim S" sort="Abdool Karim, Salim S" uniqKey="Abdool Karim S" first="Salim S" last="Abdool-Karim">Salim S. Abdool-Karim</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Communicable Diseases, Johannesburg 2131, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>National Institute for Communicable Diseases, Johannesburg 2131</wicri:regionArea><wicri:noRegion>Johannesburg 2131</wicri:noRegion></affiliation></author><author><name sortKey="Cohen, Myron" sort="Cohen, Myron" uniqKey="Cohen M" first="Myron" last="Cohen">Myron Cohen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Liao, Hua Xin" sort="Liao, Hua Xin" uniqKey="Liao H" first="Hua-Xin" last="Liao">Hua-Xin Liao</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Montefiori, David C" sort="Montefiori, David C" uniqKey="Montefiori D" first="David C" last="Montefiori">David C. Montefiori</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Park, Peter K" sort="Park, Peter K" uniqKey="Park P" first="Peter K" last="Park">Peter K. Park</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Fernandez Tejada, Alberto" sort="Fernandez Tejada, Alberto" uniqKey="Fernandez Tejada A" first="Alberto" last="Fernández-Tejada">Alberto Fernández-Tejada</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wiehe, Kevin" sort="Wiehe, Kevin" uniqKey="Wiehe K" first="Kevin" last="Wiehe">Kevin Wiehe</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Santra, Sampa" sort="Santra, Sampa" uniqKey="Santra S" first="Sampa" last="Santra">Sampa Santra</name><affiliation wicri:level="2"><nlm:affiliation>Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Deaconess Medical Center, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kepler, Thomas B" sort="Kepler, Thomas B" uniqKey="Kepler T" first="Thomas B" last="Kepler">Thomas B. Kepler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Boston University School of Medicine, Boston, MA 02118</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Saunders, Kevin O" sort="Saunders, Kevin O" uniqKey="Saunders K" first="Kevin O" last="Saunders">Kevin O. Saunders</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Sodroski, Joseph" sort="Sodroski, Joseph" uniqKey="Sodroski J" first="Joseph" last="Sodroski">Joseph Sodroski</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kwong, Peter D" sort="Kwong, Peter D" uniqKey="Kwong P" first="Peter D" last="Kwong">Peter D. Kwong</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Mascola, John R" sort="Mascola, John R" uniqKey="Mascola J" first="John R" last="Mascola">John R. Mascola</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bonsignori, Mattia" sort="Bonsignori, Mattia" uniqKey="Bonsignori M" first="Mattia" last="Bonsignori">Mattia Bonsignori</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Moody, M Anthony" sort="Moody, M Anthony" uniqKey="Moody M" first="M Anthony" last="Moody">M Anthony Moody</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Danishefsky, Samuel" sort="Danishefsky, Samuel" uniqKey="Danishefsky S" first="Samuel" last="Danishefsky">Samuel Danishefsky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Haynes, Barton F" sort="Haynes, Barton F" uniqKey="Haynes B" first="Barton F" last="Haynes">Barton F. Haynes</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28298421</idno><idno type="pmid">28298421</idno><idno type="doi">10.1126/scitranslmed.aai7521</idno><idno type="wicri:Area/PubMed/Corpus">000E35</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E35</idno><idno type="wicri:Area/PubMed/Curation">000E35</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E35</idno><idno type="wicri:Area/PubMed/Checkpoint">000E35</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E35</idno><idno type="wicri:Area/Ncbi/Merge">003F13</idno><idno type="wicri:Area/Ncbi/Curation">003F13</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F13</idno><idno type="wicri:Area/Main/Merge">000536</idno><idno type="wicri:Area/Main/Curation">000536</idno><idno type="wicri:Area/Main/Exploration">000536</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.</title><author><name sortKey="Alam, S Munir" sort="Alam, S Munir" uniqKey="Alam S" first="S Munir" last="Alam">S Munir Alam</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Aussedat, Baptiste" sort="Aussedat, Baptiste" uniqKey="Aussedat B" first="Baptiste" last="Aussedat">Baptiste Aussedat</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Vohra, Yusuf" sort="Vohra, Yusuf" uniqKey="Vohra Y" first="Yusuf" last="Vohra">Yusuf Vohra</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Meyerhoff, R Ryan" sort="Meyerhoff, R Ryan" uniqKey="Meyerhoff R" first="R Ryan" last="Meyerhoff">R Ryan Meyerhoff</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Cale, Evan M" sort="Cale, Evan M" uniqKey="Cale E" first="Evan M" last="Cale">Evan M. Cale</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Walkowicz, William E" sort="Walkowicz, William E" uniqKey="Walkowicz W" first="William E" last="Walkowicz">William E. Walkowicz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Radakovich, Nathan A" sort="Radakovich, Nathan A" uniqKey="Radakovich N" first="Nathan A" last="Radakovich">Nathan A. Radakovich</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Anasti, Kara" sort="Anasti, Kara" uniqKey="Anasti K" first="Kara" last="Anasti">Kara Anasti</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Armand, Lawrence" sort="Armand, Lawrence" uniqKey="Armand L" first="Lawrence" last="Armand">Lawrence Armand</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Parks, Robert" sort="Parks, Robert" uniqKey="Parks R" first="Robert" last="Parks">Robert Parks</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Sutherland, Laura" sort="Sutherland, Laura" uniqKey="Sutherland L" first="Laura" last="Sutherland">Laura Sutherland</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scearce, Richard" sort="Scearce, Richard" uniqKey="Scearce R" first="Richard" last="Scearce">Richard Scearce</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Joyce, M Gordon" sort="Joyce, M Gordon" uniqKey="Joyce M" first="M Gordon" last="Joyce">M Gordon Joyce</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Pancera, Marie" sort="Pancera, Marie" uniqKey="Pancera M" first="Marie" last="Pancera">Marie Pancera</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Druz, Aliaksandr" sort="Druz, Aliaksandr" uniqKey="Druz A" first="Aliaksandr" last="Druz">Aliaksandr Druz</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Georgiev, Ivelin S" sort="Georgiev, Ivelin S" uniqKey="Georgiev I" first="Ivelin S" last="Georgiev">Ivelin S. Georgiev</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Von Holle, Tarra" sort="Von Holle, Tarra" uniqKey="Von Holle T" first="Tarra" last="Von Holle">Tarra Von Holle</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Eaton, Amanda" sort="Eaton, Amanda" uniqKey="Eaton A" first="Amanda" last="Eaton">Amanda Eaton</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Fox, Christopher" sort="Fox, Christopher" uniqKey="Fox C" first="Christopher" last="Fox">Christopher Fox</name><affiliation wicri:level="2"><nlm:affiliation>Infectious Disease Research Institute, Seattle, WA 98102, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Disease Research Institute, Seattle, WA 98102</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Reed, Steven G" sort="Reed, Steven G" uniqKey="Reed S" first="Steven G" last="Reed">Steven G. Reed</name><affiliation wicri:level="2"><nlm:affiliation>Infectious Disease Research Institute, Seattle, WA 98102, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Infectious Disease Research Institute, Seattle, WA 98102</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Louder, Mark" sort="Louder, Mark" uniqKey="Louder M" first="Mark" last="Louder">Mark Louder</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bailer, Robert T" sort="Bailer, Robert T" uniqKey="Bailer R" first="Robert T" last="Bailer">Robert T. Bailer</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Morris, Lynn" sort="Morris, Lynn" uniqKey="Morris L" first="Lynn" last="Morris">Lynn Morris</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Communicable Diseases, Johannesburg 2131, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>National Institute for Communicable Diseases, Johannesburg 2131</wicri:regionArea><wicri:noRegion>Johannesburg 2131</wicri:noRegion></affiliation></author><author><name sortKey="Abdool Karim, Salim S" sort="Abdool Karim, Salim S" uniqKey="Abdool Karim S" first="Salim S" last="Abdool-Karim">Salim S. Abdool-Karim</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Communicable Diseases, Johannesburg 2131, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>National Institute for Communicable Diseases, Johannesburg 2131</wicri:regionArea><wicri:noRegion>Johannesburg 2131</wicri:noRegion></affiliation></author><author><name sortKey="Cohen, Myron" sort="Cohen, Myron" uniqKey="Cohen M" first="Myron" last="Cohen">Myron Cohen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Liao, Hua Xin" sort="Liao, Hua Xin" uniqKey="Liao H" first="Hua-Xin" last="Liao">Hua-Xin Liao</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Montefiori, David C" sort="Montefiori, David C" uniqKey="Montefiori D" first="David C" last="Montefiori">David C. Montefiori</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Park, Peter K" sort="Park, Peter K" uniqKey="Park P" first="Peter K" last="Park">Peter K. Park</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Fernandez Tejada, Alberto" sort="Fernandez Tejada, Alberto" uniqKey="Fernandez Tejada A" first="Alberto" last="Fernández-Tejada">Alberto Fernández-Tejada</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wiehe, Kevin" sort="Wiehe, Kevin" uniqKey="Wiehe K" first="Kevin" last="Wiehe">Kevin Wiehe</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Santra, Sampa" sort="Santra, Sampa" uniqKey="Santra S" first="Sampa" last="Santra">Sampa Santra</name><affiliation wicri:level="2"><nlm:affiliation>Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Beth Israel Deaconess Medical Center, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kepler, Thomas B" sort="Kepler, Thomas B" uniqKey="Kepler T" first="Thomas B" last="Kepler">Thomas B. Kepler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Boston University School of Medicine, Boston, MA 02118</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Saunders, Kevin O" sort="Saunders, Kevin O" uniqKey="Saunders K" first="Kevin O" last="Saunders">Kevin O. Saunders</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Sodroski, Joseph" sort="Sodroski, Joseph" uniqKey="Sodroski J" first="Joseph" last="Sodroski">Joseph Sodroski</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kwong, Peter D" sort="Kwong, Peter D" uniqKey="Kwong P" first="Peter D" last="Kwong">Peter D. Kwong</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Mascola, John R" sort="Mascola, John R" uniqKey="Mascola J" first="John R" last="Mascola">John R. Mascola</name><affiliation wicri:level="2"><nlm:affiliation>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bonsignori, Mattia" sort="Bonsignori, Mattia" uniqKey="Bonsignori M" first="Mattia" last="Bonsignori">Mattia Bonsignori</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Moody, M Anthony" sort="Moody, M Anthony" uniqKey="Moody M" first="M Anthony" last="Moody">M Anthony Moody</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Danishefsky, Samuel" sort="Danishefsky, Samuel" uniqKey="Danishefsky S" first="Samuel" last="Danishefsky">Samuel Danishefsky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Haynes, Barton F" sort="Haynes, Barton F" uniqKey="Haynes B" first="Barton F" last="Haynes">Barton F. Haynes</name><affiliation wicri:level="2"><nlm:affiliation>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j">Science translational medicine</title><idno type="eISSN">1946-6242</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A goal for an HIV-1 vaccine is to overcome virus variability by inducing broadly neutralizing antibodies (bnAbs). One key target of bnAbs is the glycan-polypeptide at the base of the envelope (Env) third variable loop (V3). We have designed and synthesized a homogeneous minimal immunogen with high-mannose glycans reflective of a native Env V3-glycan bnAb epitope (Man9-V3). V3-glycan bnAbs bound to Man9-V3 glycopeptide and native-like gp140 trimers with similar affinities. Fluorophore-labeled Man9-V3 glycopeptides bound to bnAb memory B cells and were able to be used to isolate a V3-glycan bnAb from an HIV-1-infected individual. In rhesus macaques, immunization with Man9-V3 induced V3-glycan-targeted antibodies. Thus, the Man9-V3 glycopeptide closely mimics an HIV-1 V3-glycan bnAb epitope and can be used to isolate V3-glycan bnAbs.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Maryland</li><li>Massachusetts</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li></settlement><orgName><li>Université de Caroline du Nord à Chapel Hill</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Alam, S Munir" sort="Alam, S Munir" uniqKey="Alam S" first="S Munir" last="Alam">S Munir Alam</name></region><name sortKey="Anasti, Kara" sort="Anasti, Kara" uniqKey="Anasti K" first="Kara" last="Anasti">Kara Anasti</name><name sortKey="Armand, Lawrence" sort="Armand, Lawrence" uniqKey="Armand L" first="Lawrence" last="Armand">Lawrence Armand</name><name sortKey="Aussedat, Baptiste" sort="Aussedat, Baptiste" uniqKey="Aussedat B" first="Baptiste" last="Aussedat">Baptiste Aussedat</name><name sortKey="Bailer, Robert T" sort="Bailer, Robert T" uniqKey="Bailer R" first="Robert T" last="Bailer">Robert T. Bailer</name><name sortKey="Bonsignori, Mattia" sort="Bonsignori, Mattia" uniqKey="Bonsignori M" first="Mattia" last="Bonsignori">Mattia Bonsignori</name><name sortKey="Cale, Evan M" sort="Cale, Evan M" uniqKey="Cale E" first="Evan M" last="Cale">Evan M. Cale</name><name sortKey="Cohen, Myron" sort="Cohen, Myron" uniqKey="Cohen M" first="Myron" last="Cohen">Myron Cohen</name><name sortKey="Danishefsky, Samuel" sort="Danishefsky, Samuel" uniqKey="Danishefsky S" first="Samuel" last="Danishefsky">Samuel Danishefsky</name><name sortKey="Druz, Aliaksandr" sort="Druz, Aliaksandr" uniqKey="Druz A" first="Aliaksandr" last="Druz">Aliaksandr Druz</name><name sortKey="Eaton, Amanda" sort="Eaton, Amanda" uniqKey="Eaton A" first="Amanda" last="Eaton">Amanda Eaton</name><name sortKey="Fernandez Tejada, Alberto" sort="Fernandez Tejada, Alberto" uniqKey="Fernandez Tejada A" first="Alberto" last="Fernández-Tejada">Alberto Fernández-Tejada</name><name sortKey="Fox, Christopher" sort="Fox, Christopher" uniqKey="Fox C" first="Christopher" last="Fox">Christopher Fox</name><name sortKey="Georgiev, Ivelin S" sort="Georgiev, Ivelin S" uniqKey="Georgiev I" first="Ivelin S" last="Georgiev">Ivelin S. Georgiev</name><name sortKey="Haynes, Barton F" sort="Haynes, Barton F" uniqKey="Haynes B" first="Barton F" last="Haynes">Barton F. Haynes</name><name sortKey="Joyce, M Gordon" sort="Joyce, M Gordon" uniqKey="Joyce M" first="M Gordon" last="Joyce">M Gordon Joyce</name><name sortKey="Kepler, Thomas B" sort="Kepler, Thomas B" uniqKey="Kepler T" first="Thomas B" last="Kepler">Thomas B. Kepler</name><name sortKey="Kwong, Peter D" sort="Kwong, Peter D" uniqKey="Kwong P" first="Peter D" last="Kwong">Peter D. Kwong</name><name sortKey="Liao, Hua Xin" sort="Liao, Hua Xin" uniqKey="Liao H" first="Hua-Xin" last="Liao">Hua-Xin Liao</name><name sortKey="Louder, Mark" sort="Louder, Mark" uniqKey="Louder M" first="Mark" last="Louder">Mark Louder</name><name sortKey="Mascola, John R" sort="Mascola, John R" uniqKey="Mascola J" first="John R" last="Mascola">John R. Mascola</name><name sortKey="Meyerhoff, R Ryan" sort="Meyerhoff, R Ryan" uniqKey="Meyerhoff R" first="R Ryan" last="Meyerhoff">R Ryan Meyerhoff</name><name sortKey="Montefiori, David C" sort="Montefiori, David C" uniqKey="Montefiori D" first="David C" last="Montefiori">David C. Montefiori</name><name sortKey="Moody, M Anthony" sort="Moody, M Anthony" uniqKey="Moody M" first="M Anthony" last="Moody">M Anthony Moody</name><name sortKey="Pancera, Marie" sort="Pancera, Marie" uniqKey="Pancera M" first="Marie" last="Pancera">Marie Pancera</name><name sortKey="Park, Peter K" sort="Park, Peter K" uniqKey="Park P" first="Peter K" last="Park">Peter K. Park</name><name sortKey="Parks, Robert" sort="Parks, Robert" uniqKey="Parks R" first="Robert" last="Parks">Robert Parks</name><name sortKey="Radakovich, Nathan A" sort="Radakovich, Nathan A" uniqKey="Radakovich N" first="Nathan A" last="Radakovich">Nathan A. Radakovich</name><name sortKey="Reed, Steven G" sort="Reed, Steven G" uniqKey="Reed S" first="Steven G" last="Reed">Steven G. Reed</name><name sortKey="Santra, Sampa" sort="Santra, Sampa" uniqKey="Santra S" first="Sampa" last="Santra">Sampa Santra</name><name sortKey="Saunders, Kevin O" sort="Saunders, Kevin O" uniqKey="Saunders K" first="Kevin O" last="Saunders">Kevin O. Saunders</name><name sortKey="Scearce, Richard" sort="Scearce, Richard" uniqKey="Scearce R" first="Richard" last="Scearce">Richard Scearce</name><name sortKey="Sodroski, Joseph" sort="Sodroski, Joseph" uniqKey="Sodroski J" first="Joseph" last="Sodroski">Joseph Sodroski</name><name sortKey="Sutherland, Laura" sort="Sutherland, Laura" uniqKey="Sutherland L" first="Laura" last="Sutherland">Laura Sutherland</name><name sortKey="Vohra, Yusuf" sort="Vohra, Yusuf" uniqKey="Vohra Y" first="Yusuf" last="Vohra">Yusuf Vohra</name><name sortKey="Von Holle, Tarra" sort="Von Holle, Tarra" uniqKey="Von Holle T" first="Tarra" last="Von Holle">Tarra Von Holle</name><name sortKey="Walkowicz, William E" sort="Walkowicz, William E" uniqKey="Walkowicz W" first="William E" last="Walkowicz">William E. Walkowicz</name><name sortKey="Wiehe, Kevin" sort="Wiehe, Kevin" uniqKey="Wiehe K" first="Kevin" last="Wiehe">Kevin Wiehe</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Morris, Lynn" sort="Morris, Lynn" uniqKey="Morris L" first="Lynn" last="Morris">Lynn Morris</name></noRegion><name sortKey="Abdool Karim, Salim S" sort="Abdool Karim, Salim S" uniqKey="Abdool Karim S" first="Salim S" last="Abdool-Karim">Salim S. Abdool-Karim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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